Anne Boleyn had Thomas Wolsey dismissed from public office and later had the Boleyn family's chaplain, Thomas Cranmer, appointed Archbishop of Canterbury. In 1533, Henry and Anne went through a secret wedding service. She soon became pregnant and there was a second wedding service, which took place in London on 25 January 1533. On 23 May 1533, Cranmer declared the marriage of Henry and Catherine null and void. Five days later, Cranmer declared the marriage of Henry and Anne to be good and valid. Soon after, the pope launched sentences of excommunication against the King and the archbishop. As a result of Anne's marriage to the King, the Church of England was forced to break with Rome and was brought under the King's control.
Mary has appeared in many, many novels (and is the lead in at least four), but her portrayals tend be pretty similar — the foolish but kindhearted sister who values love over rank and wins out in the end; the degrees of her foolishness and kindheartedness vary but that’s the basic template. (Interestingly, the first novel I’ve found in which she was explicitly the mistress of Francois I is from 1971 — since then, it’s become almost taken for granted that she was, even though the evidence for it is very thin). Making her a foil to Anne is hard for a fiction writer to resist, but I think there’s still room for a book in which she’s just as ambitious as her brother and sister, just doesn’t play her cards as well.